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    蛋白質交聯劑含有兩個或多個反應性基團,可以與蛋白或者其他分子上的官能團如氨基和巰基反應,使他們以共價鍵的方式結合在一起。蛋白質交聯劑已被廣泛應用于生命科學研究的各個分支,如蛋白質間相互作用研究、蛋白質結構分析、蛋白質組學、靶向藥物研究、蛋白質或其他分子的固相化等[1]。

    百靈威可以提供多種不同種類交聯劑,滿足您蛋白質研究中的多樣化需求。

    • 種類齊全:包括氨基反應性末端、氨基和巰基反應性末端、巰基反應性末端等
    • 性價比高
    • 現貨供應
    • 獨家供應新型化學交聯劑Leiker,具有可富集、可切斷、可定量的作用[2]。

    參考文獻:

    [1] Sinz A. Divide and conquer: cleavable cross-linkers to study protein conformation and protein–protein interactions[J]. Analytical and bioanalytical chemistry, 2017, 409(1): 33-44.

    [2] Tan D, Li Q, Zhang M J, et al. Trifunctional cross-linker for mapping protein-protein interaction networks and comparing protein conformational states[J]. Elife Sciences, 2016, 5.

       Leiker產品:

    高效富集功能

    交聯效率比傳統交聯劑高十倍以上

    有效針對復雜蛋白樣品分析

    產品編號

    產品名稱

    CAS

    純度

    包裝規格

    2138035

    Leiker, 95%

    賴氨酸特異性可富集型交聯劑

    N/A

    95%

    5mg

    10mg

    2322681

    d6-Leiker, 95%

    d6-賴氨酸特異性可富集型交聯劑

    N/A

    95%

    5mg

    10mg

       氨基-氨基交聯劑

    產品編號

    產品名稱

    CAS

    純度

    包裝規格

    146482

    BS3 (Suberic acid bis(3-sulfo-N-hydroxysuccinimide

    ester) sodium salt), 90%

    雙琥珀酰亞胺辛二酸酯鈉鹽

    82436-77-9

    90%

    25ml

    100ml

    1410146

    Disuccinimidyl tartrate, 90%

    雙琥珀酰亞胺酒石酸酯

    77658-91-4

    90%

    5mg

    25mg

    253405

    DSS (Di(N-succinimidyl)suberate), 98%

    (N-羥基琥珀酰亞胺)辛二酸酯

    68528-80-3

    98%

    1g

    5g

    296329

    DSP (Di(N-succinimidyl) 3,3'-dithiodipropionate), 97%

    (N-羥基丁二酰亞胺) 3,3'-二硫代二丙酸酯

    57757-57-0

    97%

    1g

    5g

    792543

    DTSSP (3,3'-Dithiobispropionic acid bis-sulfosuccinimidyl ester), 90%

    3,3'-二硫代雙(磺酸琥珀酰亞氨基丙酸酯)

    81069-02-5

    90%

    25mg

    100mg

    456454

    Di(N-succinimidyl) glutarate, 97%

    (N-羥基琥珀酰亞胺)戊二酸酯

    79642-50-5

    97%

    50mg

    250mg

    2740589

    Sulfo-EGS (Ethylene glycol bis(sulfosuccinimidyl succinate))

    乙二醇雙(磺基琥珀酰亞胺基琥珀酸酯)

    167410-92-6

    N/A

    10mg
    50mg

    359030

    Ethylene glycol-bis(succinic acid N-hydroxysuccinimide ester), 95%

    乙二醇-(琥珀酸 N-羥基琥珀酰亞胺酯)

    70539-42-3

    95%

    50mg

    250mg

    494597

    Sebacic acid bis(N-succinimidyl) ester, 97%

    癸二酸二(N-琥珀酰亞胺)

    23024-29-5

    97%

    100mg

    500mg

    2742043

    BS(PEG)5 (PEGylated bis(sulfosuccinimidyl)suberate)

    聚乙二醇化雙(磺基琥珀酰亞胺)辛二酸酯

    N/A

    N/A

    100mg

    2742044

    BS(PEG)9 (PEGylated bis(sulfosuccinimidyl)suberate)

    聚乙二醇9化雙(磺基琥珀酰亞胺)辛二酸酯

    1008402-79-6

    N/A

    100mg

    2331953

    mPEG-SC, average M.W.5000

    甲氧基-PEG-琥珀酰亞胺碳酸酯, 平均分子量5000

    N/A

    N/A

    1g

    5g

    350500

    p-Phenylene diisothiocyanate, 98.5%

    對苯二異硫氰酸酯

    4044-65-9

    98.5%

    5g

    475953

    7-Hydroxy-4-methylcoumarin-3-acetic acid, succinimidyl ester, 90%

    7-羥基-4-甲基香豆素-3-乙酸N-琥珀酰亞胺酯

    96735-88-5

    90%

    25mg

    928187

    3β-Amino-3-deoxydigoxigenin hemisuccinamide,

    succinimidyl ester, 80%, single isomer

    3β-氨基-3-脫氧地高辛半琥珀酰胺, 琥珀酰亞胺酯,

    單一化合物

    216299-46-6

    80%

    5mg

       氨基-巰基交聯劑

    產品編號

    產品名稱

    CAS

    純度

    包裝規格

    253343

    Sulfo-SMCC sodium, 95%

    磺基-SMCC鈉鹽

    92921-24-9

    95%

    25mg

    100mg

    918408

    LC-SPDP (Succinimidyl 6-[3(2-

    pyridyldithio)propionamido]hexanoate)

    琥珀酰亞胺基6-[32-吡啶基二硫代)丙酰胺基]己酸酯

    158913-22-5

    95%

    50mg

    1682773

    Maleimide-PEG2-succinimidyl ester, 99%

    馬來酰亞胺-PEG2-琥珀酰亞胺酯

    955094-26-5

    99%

    50mg

    250mg

    1880578

    Maleimide-PEG8-succinimidyl ester, 80%

    馬來酰亞胺-PEG8-琥珀酰亞胺酯

    756525-93-6

    80%

    50mg

    100mg

    250mg

    2744836

    Maleimide-PEG12-succinimidyl ester

    馬來酰亞胺-PEG12-琥珀酰亞胺酯

    1426151-00-9

    N/A

    50mg

    100mg

    250mg

    2743830

    PEG4-SPDP(PEGylated, long-chain SPDP crosslinker)

    聚乙二醇化的長鏈SPDP交聯劑

    N/A

    N/A

    100mg

    2743831

    PEG12-SPDP(PEGylated, long-chain SPDP crosslinker)

    聚乙二醇化的長鏈SPDP交聯劑

    N/A

    N/A

    100mg

    1880577

    PEGylated, long-chain SMCC crosslinker

    馬來酰亞胺-PEG6-琥珀酰亞胺酯

    1137109-21-7

    N/A

    50mg

    250mg

    2739697

    SBAP (Succinimidyl 3-(bromoacetamido)propionate),

    90%

    琥珀酰亞胺基3-(溴乙酰氨基)丙酸酯

    57159-62-3

    90%

    10mg
    50mg

    2740592

    SIAB (Succinimidyl (4-iodoacetyl)aminobenzoate)

    SIAB(N-琥珀酰亞胺基[4-碘乙;]氨基苯甲酸酯)

    72252-96-1

    95%

    50mg

    2739698

    SM(PEG)24 (PEGylated, long-chain SMCC crosslinker)

    聚乙二醇化的長鏈SMCC交聯劑

    N/A

    N/A

    25mg

    100mg

    2740596

    Sulfo-EMCS (N-ε-Maleimidocaproyl-oxysulfosuccinimide ester)

    N-ε-馬來酰亞胺己酰氧基磺基琥珀酰亞胺酯

     N/A

    N/A

    50mg

    990207

    Sulfo-KMUS(N-(κ-Maleimidoundecanoyloxy)

    sulfosuccinimide ester)

    N-(κ-馬來酰亞胺十一烷酰氧基)磺基琥珀酰亞胺酯

     N/A

    96%

    50mg

    199829

    Sulfo-LC-SPDP (Sulfosuccinimidyl 6-(3'-(2-

    pyridyldithio)propionamido)hexanoate), 90%

    磺基琥珀酰亞胺基6-[3′-(2-吡啶基二硫代)丙酰胺基]己酸

    169751-10-4

    90%

    50mg

    2740595

    Sulfo-MBS (m-Maleimidobenzoyl-

    N-hydroxysulfosuccinimide ester)

    間馬來酰亞胺苯甲;-N-羥基磺基琥珀酰亞胺酯

    103848-62-0

    95%

    10mg

    50mg

    2740597

    Sulfo-SMPB (Sulfosuccinimidyl 4-(N-

    maleimidophenyl)butyrate)

    4-(N-馬來酰亞胺苯基)丁酸磺基琥珀酰亞胺基酯

     N/A

    95%

    10mg
    50mg

    771214

    Sulfo-SIAB (Sulfosuccinimidyl (4-iodoacetyl)aminobenzoate)

    磺基-N-琥珀酰亞胺基(N-碘乙;)氨基苯甲酸酯

    144650-93-1

    N/A

    10mg

    50mg

    1318115

    Sulfo-N-succinimidyl 4-maleimidobutyrate sodium salt

    磺基-N-琥珀酰亞胺基4-馬來酰亞胺丁酸鈉鹽

    185332-92-7

    90%

    5mg

    25mg
    50mg

    415447

    MBS (3-Maleimidobenzoic acid N-hydroxysuccinimide

    ester)
    3-
    馬來酰亞胺基苯甲酸琥珀酰亞胺酯, 98%

    58626-38-3

    98%

    100mg

    250mg

    389641

    SMPB (4-(4-Maleimidophenyl)butyric acid

    N-hydroxysuccinimide ester)

    4-(4-馬來酰亞胺基苯基)丁酸琥珀酰亞胺酯, 98%

    79886-55-8

    98%

    100mg

    551313

    SPD (3-(2-Pyridyldithio)propionic acid N-hydroxysuccinimide ester)

    3-(2-吡啶二硫代)丙酸 N-琥珀酰亞胺酯, 96%

    68181-17-9

    96%

    100mg

    444282

    SIA (N-Succinimidyl iodoacetate)
    碘乙酸N-琥珀酰亞胺酯, 95%

    39028-27-8

    95%

    100mg

    500mg

    168877

    Bromoacetic acid N-hydroxysuccinimide ester, 95%
    溴乙酸 (N-羥基琥珀酰亞胺), 95%

    42014-51-7

    95%

    250mg

    1g

    316626

    GMBS (4-Maleimidobutyric acid

    N-hydroxysuccinimide ester) , 98%
    4-
    馬來酰亞胺基丁酸N-羥基琥珀酰亞胺酯

    80307-12-6

    98%

    100mg

    250mg

    141636

    3-(Maleimido)propionic acid N-hydroxysuccinimide

    ester, 99%

    3-馬來酰亞胺基丙酸(N-羥基琥珀酰亞胺)

    55750-62-4

    99%

    100mg

    1g

    229882

    Maleimidoacetic acid N-hydroxysuccinimide ester,

    98%

    馬來酰亞胺基乙酸琥珀酰亞胺酯

    55750-61-3

    98%

    10mg

    50mg

    245256

    6-Maleimidohexanoic acid N-hydroxysuccinimide

    ester, 98%

    6-(馬來酰亞胺基)己酸(N-羥基琥珀酰亞胺)

    55750-63-5

    98%

    100mg

    1g

    467057

    N-Succinimidyl-4-(maleimidomethyl)cyclohexane-

    1-carboxylate, 99%

    N-琥珀酰亞胺基-4-(馬來酰亞胺基甲基)環己烷-1-羧酸酯

    64987-85-5

    99%

    100mg

    250mg

       巰基-巰基交聯劑

    產品編號

    產品名稱

    CAS

    純度

    包裝規格

    2739702

    1,8-Bismaleimido diethylene glycol

    1,8-雙馬來酰亞胺基二甘醇

    N/A

    90%

    50mg

    590530

    1,2-Bismaleimidoethane, 95%

    1,2-(馬來酰亞胺)乙烷

    5132-30-9

    95%

    25mg

    100mg

    454643

    1,6-Bismaleimidohexane, 97%

    1,6-(馬來酰亞胺基)己烷

    4856-87-5

    97%

    25mg

    100mg

    2739701

    BM(PEG)3 (1,11-Bismaleimido-triethyleneglycol)

    1,11雙馬來酰亞胺基三甘醇

    86099-06-1

    98%

    25mg

    50mg

    100mg

    2742604

    DTME (Dithiobismaleimidoethane)

    二硫代雙馬來酰亞胺甲烷

    N/A

    N/A

    50mg

       巰基-羰基交聯劑

    產品編號

    產品名稱

    CAS

    純度

    包裝規格

    2740604

    KMUH (N-(κ-Maleimidoundecanoic acid) hydrazide,

    trifluoroacetic acid salt)

    KMUH(N-(κ-馬來酰亞胺基十一烷酸)酰肼

    1593661-78-9

    97%

    50mg

    507400

    PDPH (3-(2-Pyridyldithio)propionyl hydrazide)

    3-2-吡啶基二硫代)丙酰肼

    115616-51-8

    95%

    25mg

    50mg

    424909

    EMCH (N-(ε-Maleimidocaproic acid) hydrazide,

    trifluoroacetic acid salt), 95%

    6-馬來酰亞胺己酰肼三氟乙酸鹽

    151038-94-7

    95%

    50mg

    250mg

    380294

    4-(4-N-Maleimidophenyl) butyric acid hydrazide, 80%

    4-(4-N-馬來酰亞胺苯基)丁酸酰肼

    157797-94-9

    80%

    50mg

       光反應性交聯劑

    產品編號

    產品名稱

    CAS

    純度

    包裝規格

    350636

    4-Benzoylbenzoic acid N-succinimidyl ester, 97%

    4-苯甲酰苯甲酸-N-琥珀酰亞胺酯

    91990-88-4

    97%

    50mg

    250mg

       其他反應基團交聯劑

    產品編號

    產品名稱

    CAS

    純度

    包裝規格

    902042

    Glutaraldehyde, 50 wt.% solution in H2O

    戊二醛, 50 wt.% 水溶液

    111-30-8

    N/A

    25ml

    100ml

    500ml

    211112

    EDC (N-(3-Dimethylaminopropyl)-N'-ethylcarbodiimide

    hydrochloride)

    N-(3-二甲氨基丙基)-N'-乙基碳二亞胺鹽酸鹽

    25952-53-8

    99%

    1g

    10g

    50g

    100g

    117997

    NHS(N-Hydroxysuccinimide)

    N-羥基琥珀酰亞胺

    6066-82-6

    98%

    5g

    25g

    100g

    1921678

    N-DiZPK, 98%

    N-DiZPK

    1337883-32-5

    98%

    10mg

    202233

    Adipic acid dihydrazide, 98%

    己二酸二酰肼

    1071-93-8

    98%

    5g

    25g

    250g

    2669832

    O-DiZPK, 98%

    O-DiZPK

    N/A

    98%

    10mg


     

     

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